If you provide additional keywords, you may be able to browse through our database of Scientific Response Documents. Severe hepatic dysfunction: max 8mg/day. The dosage of ondansetron for cats and dogs can vary on the basis of the reason for the prescription. Children 1 month to 17 years old: Children and adolescents will receive ondansetron injections instead of Zofran tablets Zofran dosage for children Ondansetron is used in children as young as 6 months old to prevent nausea provoked by cancer chemotherapy or as young as 1 month old to prevent postoperative nausea. . Before using Ondansetron Injection, inform your doctor about your current list of medications, over the counter products (e.g. Ondansetron Injection, USP 2 mg per mL is a clear, colorless, nonpyrogenic, sterile solution available as a 2 mL single-dose vial and 20 mL multi-dose vial. The dose of Zofran for hyperemesis gravidarum requiring hospitalization is a maximum of 10 milligrams via intravenous therapy (IV) every 8 hours. Zofran Solution for Injection or Infusion contains sodium citrate and sodium chloride. The general doggy dosage is 1 mg/ per pound, so that's what your vet has prescribed - most people tend to go too low on the dosage. Ondansetron orally disintegrating tablet may cause drowsiness. Zofran; Descriptions. Ondansetron Injection Warnings/Precautions: <4 months of age (monitor closely). When ondansetron is used to prevent nausea and vomiting caused by chemotherapy, it is usually given 30 minutes before the start of chemotherapy. Dosage may be repeated twice, administered 4 and 8 hours after the initial dose. cold sensation. Adults: The recommended adult intravenous dosage of Ondansetron is three .15-mg/kg doses up to a maximum of 16 mg per dose. Drug information provided by: IBM Micromedex. By rectum Adult Common side effects of Onset 2 MG Injection are constipation, headache and dizziness. Caution: Dilution of Zofran Injection is required in adult and pediatric patients prior to administration. To prevent nausea and vomiting caused by chemotherapy, ondansetron is given 30 minutes before the start of chemotherapy. Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly to treat nausea and vomiting following chemotherapy. Prevention of Postoperative Nausea and/or Vomiting The intravenous dose is 0.05 to 0.1 mg per pound (0.1 to 0.2 mg/kg). Nausea and vomiting associated with cancer chemotherapy- 24 mg as a single. This medicine is also used to prevent and treat nausea and vomiting that may happen after surgery. Doses of Ondansetron Injection, USP, 2 mg/mL is a clear, colorless, nonpyrogenic, sterile solution available as a 2 mL single-dose vial and 20 mL multiple-dose vial. vitamins, herbal supplements, etc. If you are using the premixed bags, after removing the bag from the outer wrapper, check for small leaks by squeezing the container firmly. Mean bioavailability in healthy subjects, following administration of a single 8-mg tablet, is approximately 56%. Dosing will be based on weight. The dose range of ondansetron solution for injection or infusion is 8-32 mg a day and selected as shown below. Call your doctor at once if you have: headache with chest pain and severe dizziness, fainting . The peak plasma level of OND was attained within 10 min after application to the nasal mucosa of the rat. ondansetron 1 mg, oral, fda approved prescription anti-emetic, for use as a complete therapeutic substitute for an iv anti-emetic at the time of chemotherapy treatment, not to exceed a 48 hour dosage regimen 00078067919 zofran odt 4 mg tablet 08/30/2017 12/31/2019 j9214 injection, interferon, alfa-2b, recombinant, 1 million units 00085111001 Our scientific content is evidence-based, scientifically balanced and . The rate of administration should not be less than 30 seconds, preferably over 2 to 5 minutes. Ondansetron is usually given just before your surgery begins, or within 2 hours after surgery. ( 4) Concomitant use of apomorphine. Multiday, single-dose administration of a 24 mg dosage has not been studied. Ondansetron injection should be diluted in 50 mL of 5% Dextrose Injection or 0.9% Sodium Chloride Injection before administration. (4, 7.2) WARNINGS AND PRECAUTIONS WHAT IS Ondansetron? No single dose should exceed 16 mg/dose IV. AUC from a 16-mg Includes Ondansetron indications, dosage/administration, pharmacology, mechanism/onset/duration of action, half-life, dosage forms, interactions, warnings, adverse reactions, off-label uses and more. Dosage Forms And Strengths. More typical pregnancy nausea is managed by a much . Ondansetron systemic exposure does not increase proportionately to dose. Administration: Each 1 mL of aqueous solution in the 2-mL single-dose vial contains 2 mg of ondansetron as the hydrochloride dihydrate; 9.0 mg of sodium chloride, USP; and 0.5 mg of citric acid Ondansetron Injection should be diluted in 50 mL of 5% Dextrose Injection or 0.9% Sodium Chloride Injection before administration. It can also cause other side effects. Ondansetron HCl is a white to off-white powder that is soluble in water and normal saline. I had a dog who needed it a good 8 months or more of every year and it never caused any trouble. SLIDESHOW Read More 1.2 Prevention of Postoperative Nausea and/or Vomiting Adults: The recommended adult intravenous dosage of ondansetron is three 0.15 mg/kg doses up to a maximum of 16 mg per dose [see CLINICAL PHARMACOLOGY (12.2)]. elevated liver function test results. injection-site pain. pregnancy, upcoming surgery, etc. Caution: Dilution of Ondansetron Injection is required in adult and pediatric patients prior to administration. May mask progressive ileus and/or gastric distention. Emetogenic chemotherapy and radiotherapy For patients receiving emetogenic chemotherapy or radiotherapy ondansetron can be given either by intravenous or other routes of administration, however this product is for intravenous use only. Pediatric Use Or, may use 4mg IM undiluted as a single injection. Nausea and Vomiting Adult: PO 8 mg 30 min before chemotherapy, then q8h times 2 more doses Adult/ Child: IV 6 mo-18 y, 0.15 mg/kg or 32 mg infused over 15 min beginning 30 min before start of chemotherapy, followed by 0.15 mg/kg 4 and 8 h after first dose of ondansetron, may also give 8 mg bolus, then 1 mg/h by continuous infusion (max: 32 mg/d), or 32 mg as single dose Order for patient CC reads, "ondansetron 4mg subcutaneously once as loading dose, then infuse subcutaneously at a continuous rate of .5mg/hr with a bolus dose 0.25mg every 30 minutes as needed for nausea/vomiting." Ondansetron solution for injection is available in 2mg/mL vials and 32mg/50mL premixed bags with dextrose 5% Ondansetron Injection, USP (2 mg/mL): 2 mL single dose vial and 20 mL multiple dose vial. The first dose of ondansetron is usually taken before the start of your surgery, chemotherapy, or radiation treatment. 3 How to have Zofran Solution for Injection or Infusion Congenital long QT syndrome: avoid. ZOFRAN Injection Dosage Intravenous Infusion Rate ; Adults > 12 yrs ; 4 mg x 1 : over 2 - 5 min : Pediatrics (> 40 kg) 4 mg x 1 ; over 2 - 5 min : Pediatrics ( 40 kg) 0.1 mg/kg x 1 : over 2 - 5 min In patients with severe hepatic impairment, a total daily dose of 8 mg should not be exceeded. The first dose is infused over 15 minutes beginning 30 minutes before the start of emetogenic chemotherapy. or Intramuscular (I.M.) (2.4) Injection: The recommended I.V. FDA previously issued a DSC about the ongoing safety review of ondansetron in September 2011. Ondansetron may cause serious side effects. More common side effects The more common side effects of ondansetron can include: headache. numbness and tingling. Ondansetron Injection is approved for patients aged 6 months and older. The recommended dosage for adult and pediatric patients 6 months of age and older for prevention of nausea and vomiting associated with emetogenic chemotherapy is 0.15 mg/kg per dose for 3 doses (maximum of 16 mg per dose). Maximum dose: 16 mg (per dose) Comments: The injection formulation should be diluted in 50 mL prior to IV administration. Sterile Injection for Intravenous (I.V.) ).Some health conditions may make you more susceptible to the side-effects of the drug. Chemotherapy that causes moderate nausea and vomiting: 8 mg dose taken 30 minutes before the start of chemotherapy, with another 8 mg dose taken 8 hours after the first dose. Onset 2 MG Injection is an antiemetic medicine used to treat and prevent nausea and vomiting caused by surgery, cancer medicines (chemotherapy) or radiation therapy.